UltraNuclease is a genetically engineeredendonuclaese derived from Serratia marcescens,which is capable of degrade DNA or RNA,either double or single stranded, linear or circular under a wide range of condition,completely degrade nucleic acids into 5’-monophosphate oligonucleotides with 3-5base length. After genetic engineering modification, theproduct was fermented, expressed, and purifiedin Escherichia coli (E. coli), which reducestheviscosity of cell supernatant and cell lysate inscientific research, but also improve the purification efficiency and functional research ofprotein. It can also be used in the gene therapy,virus purification, vaccine production, proteinand polysaccharide pharmaceutical industry as a host residue nucleic acid removal reagent.